Grace Thomas, Ph.D.
Associate Professor



Ph.D. in Synthetic Organic Chemistry

Previous Positions 

Scientific Research Officer,Institute for Intensive Research in Basic Sciences, Mahatma Gandhi University, Kottayam.

Patent Specialist, Speridian Technologies, Technopark, Trivandrum.

C.S.I.R Post Doctoral Fellow,School of Chemical Sciences, Mahatma Gandhi University, Kottayam.

Research Interests

  • Synthesis of enantiomerically pure metal organic frameworks
  • Synthesis of Natural products
  • Exploration of Chiral pool for industrially potential molecular entities like chiral stationary phases, chiral molecular sensors etc.
  • Design and synthesis of chiral auxiliaries and catalysts.
  • Self assembling and replicating molecules-supra molecular chemistry.
  • Natural product exploration.

Consultancy Services

Patent drafting

Technical writing

Patent searches for back ground art.

Claim Chart Analysis

Projects undertaken

Principal Investigator : Semi synthetic strategy leading to structurally diverse molecules based on Pyrrolidinediones (UGC, Minor, completed)

Co-Investigator : Ex-chiral pool synthesis towards few molecules of anticancer & anti tuberculosis likeness (CSIR, Major, Completed)

Co-Investigator : Synthesis of few medicinally important chiral molecules derived from renewable resources (DST , Major, Completed)

Publications :

  1. Ibnusaud, I.; Thomas,G.; Sasi, P.V. A Novel Chiral derivatives of Garcinia acid bearing lactone ring moiety and process for preparing the same. S. patent no 6,489,492B2 ( 3 rd December, 2002 ) CAN 137:247883
  2. Ibnusaud, I.; Thomas, G.; Sasi, P.V. Novel Chiral derivatives of Garcinia acid and a process for preparing the same. Indian patent no. 192471
  3. Ibnusaud, I.;Thomas,G.; Sasi, P.V. A process of preparing novel chiral derivatives of Garcinia acid bearing Lactone Moiety Indian patent no.  1426/Del/03, 2003
  4. Deenamma Habel, Divya S. Nair, Grace Thomas,Simimole Haleema, Chithra Gopinath, Matthew Fritz, Andrew R. Puente, Jordan L. Johnson,Prasad L. Polavarapu and Ibrahim Ibnusaud*. Natural Product-Derived Chiral Pyrrolidine-2,5-diones, Their Molecular Structures and Conversion to Pharmacologically Important Skeletons. J. Nat. Prod.2020, 83, 7, 2178–2190
  5. Polav. arapu P.L.,   Ibnusaud I, Thomas G, Habel D and  Sebastian D A Single Chiroptical Spectroscopic Method May Not Be Able To Establish the Absolute Configurations of Diastereomers: Dimethylesters of Hibiscus and Garcinia Acids J. Phys. Chem. A, 2011, 115 (22), pp 5665–5673
  6. Ibnusaud, I. and Thomas,G. Biologically interesting chiral 3,4-disubstituted pyrrolidines from optically active Hydroxycitric acid lactones., Tetrahedron Letters, 2003, 44, 1247-1249
  7. Nair D.S, Habel H, Thomas G and I.Ibnusaud. Synthesis of enantiopure 3-substituted ,3,4- disubstituted pyrrolidinediones and related isoquinoline alkaloid, Proceedings of 247th American Chemical Society National Meeting and Exposition, Chemistry amd Materials for energy Held at Dallas, TX, March 2014.
  8.  I.Ibnusaud, Grace Thomas, Deepak chandran, H. Simimole; Synthesis Of Enantiomerically pure γ-butyrolactone based molecules-A Green Approach. Book of abstracts of 16th international symposium in Chirality (Chirality 2004) held at New York University, New York during July11-14, 2004, (Bronze medal received)